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Malaria is a great concern for global health and accounts for a large amount of morbidity and mortality, particularly in Africa, with sub-Saharan Africa carrying the greatest burden of the disease. Malaria control tools such as insecticide-treated bed nets, indoor residual spraying, and antimalarial drugs have been relatively successful in reducing the burden of malaria; however, sub-Saharan African countries encounter great challenges, the greatest being antimalarial drug resistance. Chloroquine CQ was the first-line drug in the 20th century until it was replaced by sulfadoxine—pyrimethamine SP as a consequence of resistance. The extensive use of these antimalarials intensified the spread of resistance throughout sub-Saharan Africa, thus resulting in a loss of efficacy for the treatment of malaria. SP was replaced by artemisinin-based combination therapy ACT after the emergence of resistance toward SP; however, the use of ACTs is now threatened by the emergence of resistant parasites.
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Michele and the rest of the Glee cast earned a Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Comedy Series from four nominations and three Grammy Award nominations for music recorded for the series, also spawning multiple hits on the Billboard charts. Michele made her feature film debut in New Year's Eve , and was signed to Columbia Records in She released her debut single the following year, " Cannonball ", followed by her debut studio album, Louder , which debuted at number 4 on the Billboard chart in the United States. In , she released Christmas in the City , her third studio album.
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